December 8, 2025BloodOpen Access

Multidimensional profiling of dendritic cell and monocyte subsets in sickle cell anemia: Correlation with clinical and inflammatory parameters

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Circulating plasmacytoid DCs and monocytes exhibited distinct profiles, indicating altered immune responses in sickle cell anemia patients.
Analysis correlated bilirubin levels with iDC frequency, highlighting a connection to inflammatory cytokine expression in disease severity.
Multiparametric flow cytometry was implemented to delineate dendritic cell and monocyte subpopulations and their activation states.
Variation in regulatory T cell frequencies associated with monocyte and dendritic cell activity, emphasizing roles in immune modulation.

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Analysis highlights elevated inflammatory cytokines and monocyte iron uptake in sickle cell anemia patients, suggesting immune dysregulation.

Fernando Ferreira Costa (2025) studied this question.

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Analysis highlights elevated inflammatory cytokines and monocyte iron uptake in sickle cell anemia patients, suggesting immune dysregulation.