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December 8, 2025BloodOpen Access

Trends in mortality from deep vein thrombosis and pulmonary embolism as multiple causes of death in u.S. adults aged ≥65 years (1999–2023): A CDC wonder analysis

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Authors

HWHakim WazirNTNayanika TummalaASAdnan Sharif

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Overview

Mortality trends increased for thromboembolic complications in older adults, highlighting the need for targeted prevention strategies.

Key Points

  • Mortality from deep vein thrombosis and pulmonary embolism among U.S. adults aged ≥65 increased steadily since 1999, reaching 76,055 deaths.
  • The age-adjusted mortality rate rose from 5.59 to 6.94 per 100,000, with significant disparities noted among different races and regions.
  • Data sourced from the CDC WONDER database covered 1999–2023, stratifying results by sex, race, and urbanization levels.
  • These findings suggest urgent development of prevention strategies to address rising mortality in high-risk populations.

Cite This Study

Wazir et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd28https://doi.org/10.1182/blood-2025-7993
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends and Disparities in Pulmonary Embolism Mortality in the United States, 1999– 20232025
  2. 2Temporal trends in hypertension and pulmonary embolism–related mortality in the United States: A population-based study using CDC WONDER, 2000–20202025
  3. 3Trends and Disparities in Mortality due to Pulmonary Embolism Among Adults With Atrial Fibrillation From 1999 to 2020: Insights From the <scp>CDC</scp> <scp>WONDER</scp> Database2026
  4. 4Mortality from pulmonary embolism among patients with lung and bronchus malignancies: National trends and forecasting from CDC WONDER (1999–2030).2026
  5. 5Trends in mortality due to lymphoma and pulmonary embolism in the United States, 1999–2020: A CDC wonder database population analysis2025