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December 8, 2025BloodOpen Access

CDK7 enables adaptive gene transcription required by stromal cells to support distinct T-cell lymphoma phenotypes and represents a novel microenvironment-directed therapeutic target

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Authors

GIGiorgio InghiramiNZNahuel Zamponi

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Overview

Observational analysis shows changes in cytokine levels in stromal cells to support T-cell lymphoma, suggesting CDK7 may be a therapeutic target.

Key Points

  • CDK7 activity alters cytokine expression in stromal cells, pushing T-cell lymphoma growth.
  • Treatment with YKL-5-124 reduced cytokine levels, indicating a significant therapeutic potential.
  • Analysis utilized patient-derived tumor xenografts to assess the role of stromal cells in T-cell lymphoma progression.
  • These findings highlight the role of collagens and stromal interactions in lymphoma pathology.

Cite This Study

Inghirami et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc87https://doi.org/10.1182/blood-2025-554
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