Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Mutations landscape of relapsed refractory multiple myeloma patients prior to anti-BCMA treatment

View Full Paper
Ask AI
Bookmark
Share

Authors

NNNour NassourSPSarah Parker

Discussion

Loading...

Member takes

Overview

Genomic sequencing reveals resistance mechanisms and predictive markers impacting progression-free survival in multiple myeloma patients treated with anti-BCMA therapies.

Key Points

  • Patients with mutations in TP53 and DNMT3A have lower progression-free survival and overall survival after anti-BCMA therapy.
  • Next-generation sequencing of 144 genes was used to assess mutational burden in relapsed refractory multiple myeloma patients.
  • The study included 47 BCMA-naïve patients and distinguished between responders and non-responders based on treatment outcomes.
  • Identification of predictive markers is crucial for optimizing treatment strategies and improving patient outcomes in myeloma.

Cite This Study

Nassour et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dbf5https://doi.org/10.1182/blood-2025-7484
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of prior BCMA-targeted therapy on CAR-T expansion and host T-cell phenotypes in patients with Relapsed/Refractory multiple myeloma receiving BCMA CAR-T therapy2025
  2. 2Survival outcomes of multiple myeloma patients previously exposed to BCMA-targeted therapies in the honeur european network2025
  3. 3BCMA-CART therapy in 29 cases of relapsed or refractory multiple myeloma:a retrospective study2025
  4. 4Ultra high-risk multiple myeloma with early mortality despite quad-class and BCMA-directed therapies: Clinical and molecular insights2025
  5. 5Evidence for pre-existing myeloma cells with a gene expression pattern associated with resistance to BCMA CAR T cells.2025