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December 8, 2025BloodOpen Access

Sequential therapy with fitcy preparative regimen for patients above the age of 70 years with active AML – a single center retrospective analysis

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Authors

OAOdelia AmitGFGil FridbergYMYakir Moshe

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Overview

Retrospective analysis shows sequential therapy improves survival in elderly AML patients, highlighting the role of venetoclax and GVHD prophylaxis.

Key Points

  • Complete remission achieved in 90% of evaluable patients after treatment with venetoclax-based therapy.
  • Cumulative incidence of overall survival at 3 years was 42%, demonstrating effectiveness of sequential therapy.
  • Observational analysis reveals that venetoclax use and improved GVHD prophylaxis are associated with higher survival rates.
  • Cumulative incidences of acute and chronic GVHD post-transplantation were significant but manageable, supporting the regimen's safety.

Cite This Study

Amit et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236dba1https://doi.org/10.1182/blood-2025-5973
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