December 8, 2025BloodOpen Access

Longitudinal analysis of T-cell phenotype and function during bispecific antibody therapy

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Discussion

Observational analysis shows T-cell exhaustion and differentiation changes in lymphoma patients receiving bispecific antibody therapy.

Elevated PD-1 expression persisted throughout bispecific antibody treatment, indicating ongoing T-cell exhaustion.
Participants demonstrated altered T-cell differentiation, with declines in naïve and central memory T-cells during therapy.
Flow cytometry was utilized to assess T-cell phenotype and function alongside antiviral T-cell responses.
These findings suggest that T-cell exhaustion may limit durable responses, warranting further immune monitoring.

Akiva Diamond (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

Bookmark

Authors

Observational analysis shows T-cell exhaustion and differentiation changes in lymphoma patients receiving bispecific antibody therapy.

Elevated PD-1 expression persisted throughout bispecific antibody treatment, indicating ongoing T-cell exhaustion.
Participants demonstrated altered T-cell differentiation, with declines in naïve and central memory T-cells during therapy.
Flow cytometry was utilized to assess T-cell phenotype and function alongside antiviral T-cell responses.
These findings suggest that T-cell exhaustion may limit durable responses, warranting further immune monitoring.

Akiva Diamond (2025) studied this question.

View Full Paper

Ask AI

Bookmark