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December 8, 2025Blood

Prognostic value of combining beta-2-microglobulin and total metabolic tumor volume in patients with follicular lymphoma: A post-hoc analysis of the relevance trial

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Authors

LYLoïc YsebaertRRRomain RicciDTDavid Tonnelet

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Overview

Post-hoc analysis shows combining beta-2-microglobulin and tumor volume predicts progression-free survival in lymphoma, suggesting better treatment strategies.

Key Points

  • The combined score utilizing beta-2-microglobulin and tumor volume yielded better prognostic predictions.
  • Progression-free survival was confirmed as a key endpoint, where higher ratios indicated increased risk of progression or death.
  • Assessment involved Cox models with penalized splines, showcasing model fit and improvement over traditional scores.
  • This approach underscores the significance of incorporating metabolic tumor volume and biomarkers into treatment decisions for lymphoma.

Cite This Study

Ysebaert et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db2bhttps://doi.org/10.1182/blood-2025-5361
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