December 8, 2025BloodOpen Access

Hemoglobin uptake by liver endothelium prevents von Willebrand factor clearance in sickle cell disease

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Discussion

Research finds hemostatic imbalance increases vascular complications in sickle cell disease, suggesting novel therapeutic avenues.

LSEC dysfunction significantly enhances von Willebrand factor levels in sickle cell disease, leading to vascular complications.
Baseline sickle cell disease mice showed increased von Willebrand factor expression, correlating with end-organ damage.
Assessment involved acute models of liver endothelium-specific hemoglobin accumulation in sickle cell disease mice.
Targeting liver hemoglobin clearance pathways could improve patient outcomes in sickle cell disease.

Wołosowicz et al. (2025) studied this question.

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