December 8, 2025Blood

Epidemiological and molecular analysis of thalassemia (Beta Globin Gene) in the heterogeneous population of gwadar, Pakistan

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Iron overload complications significantly impacted thalassemia patients, especially with abnormal hormonal levels observed.
A total of 50 deaths were recorded, leading to an 18% mortality rate among patients due to complications such as severe diarrhea and HIV.
Molecular analysis involved DNA extraction and Sanger sequencing, revealing prevalent mutations like IVS-I-5 (G>C) and its link to transfusion dependency.
The findings underscore the urgent need for enhanced genetic screening programs and improved infection control measures in Gwadar.

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Implication

Epidemiological analysis reveals thalassemia's impact on mortality linked to iron overload and HIV in Gwadar, highlighting the need for genetic screening and infection control measures.

Cite This Study

Ali et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dac9 https://doi.org/10.1182/blood-2025-4672

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Implication

Epidemiological analysis reveals thalassemia's impact on mortality linked to iron overload and HIV in Gwadar, highlighting the need for genetic screening and infection control measures.

Epidemiological and molecular analysis of thalassemia (Beta Globin Gene) in the heterogeneous population of gwadar, Pakistan

Key Points

Discussion

Implication

Cite This Study

Epidemiological and molecular analysis of thalassemia (Beta Globin Gene) in the heterogeneous population of gwadar, Pakistan

Key Points

Discussion

Implication

Cite This Study