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December 8, 2025BloodOpen Access

Targeted deep sequencing of myeloma in a multi-institutional clinical workflow

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Authors

AYAndrew J. YeeDCDiana CirsteaPKPrabhjot Kaur

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Overview

Evaluation of PlasmaSeq reveals 71% actionable insights in multiple myeloma samples, indicating benefits over traditional FISH.

Key Points

  • PlasmaSeq identified somatic mutations in 59% of multiple myeloma samples, significantly enhancing genomic insights.
  • Next-generation sequencing revealed 25 unique abnormalities not detected by FISH, underscoring its higher sensitivity.
  • Assessment of 155 bone marrow aspirate samples demonstrated a 100% diagnostic rate for clonal cases using PlasmaSeq.
  • These findings suggest a shift to sequencing-based profiling in multiple myeloma for improved risk stratification and treatment targeting.

Cite This Study

Yee et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da84https://doi.org/10.1182/blood-2025-4026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated cell-free DNA and RNA sequencing recapitulates bone marrow genomic and transcriptomic alterations in multiple myeloma2025 · 1 citations
  2. 2Replacing FISH with a comprehensive integrated approach for tumor genotyping and immune monitoring in multiple myeloma: The flagship study2025 · 1 citations
  3. 3Comprehensive DNA/RNA-based targeted sequencing for molecular karyotyping and clonality assessment in newly diagnosed multiple myeloma patients2025
  4. 4Liquid biopsy for non-invasive molecular characterization and measurable residual disease analysis in multiple myeloma2025
  5. 5Comprehensive characterization of multiple myeloma genomes from bone marrow or peripheral blood with a novel clinical assay enables identification of resistance mechanisms2025