Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Impact of 7-day versus standard venetoclax exposure in combination with azacitidine in frontline AML settings: A real-world analysis from the venaura retrospective multicenter study

View Full Paper
Ask AI
Bookmark
Share

Authors

UTUrbain Tauveron-JalenquesETEmmanuelle TavernierNMNatacha Mauz

Discussion

Loading...

Member takes

Overview

Real-world analysis shows 7-day venetoclax regimen has lower response rates in acute myeloid leukemia, implying caution with abbreviated schedules.

Key Points

  • Short-course venetoclax treatment resulted in a lower overall response rate compared to standard treatment.
  • Response rates were 40% for short-course versus 57% for standard, indicating significant differences based on duration.
  • Data were collected retrospectively from 10 centers across France using the VENAURA registry with 775 patients.
  • Findings highlight the importance of assessing patient eligibility and potential risks for those receiving shorter treatment schedules.

Cite This Study

Tauveron-Jalenques et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da65https://doi.org/10.1182/blood-2025-3398
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dose-adjusted treatment with venetoclax for 7 days and 5-azacitidine or decitabine in patients with Acute Myeloid Leukemia or higher risk myelodysplastic neoplasms2025
  2. 2Real-world outcomes of shortened venetoclax course plus decitabine in newly diagnosed acute myeloid leukemia2025 · 1 citations
  3. 3Venetoclax combined with azacitidine in elderly acute myeloid leukemia: A retrospective comparison of 14-day vs 28-day dosing regimens2025 · 2 citations
  4. 4Efficacy of a 14-day venetoclax regimen in combination with a hypomethylating agent for Acute Myeloid Leukemia: A single-center retrospective analysis2025
  5. 5Real-world experience in the first-line treatment of Acute Myeloid Leukemia with ven-aza: Optimizing venetoclax exposure for better outcomes2025