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December 8, 2025Blood

Central nervous system involvement in pediatric Acute Myeloid Leukemia: A comprehensive report from the AML-BFM group

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Authors

KKKatje KleyerMSMichael M. Schuendeln

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Overview

Observational analysis found no significant survival differences in pediatric patients with CNS involvement in acute myeloid leukemia, indicating careful treatment monitoring is essential.

Key Points

  • CNS involvement showed no difference in 5-year overall survival rates of 78.3% vs. 75.5% for CNS negative patients.
  • Higher leukocyte counts significantly correlated with CNS involvement, 49.2 vs. 92.6 x10^9/L, p<0.001.
  • The majority of patients with CNS involvement achieved clearance of cerebrospinal fluid blasts after intrathecal treatments, with minimal persistence observed.
  • Despite previously high-risk associations, no survival benefit was shown with cranial irradiation for CNS positive individuals.

Cite This Study

Kleyer et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da61https://doi.org/10.1182/blood-2025-3403
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