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December 8, 2025BloodOpen Access

Multi-centre real-world outcome of patients with Richter transformation receiving CD19-directed commercial CAR T-cell therapy in Australia.

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Authors

JLJian LiMDMark R. DowlingVVVinay Vanguru

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Overview

Multi-centre analysis reveals CAR T-cell therapy achieves 61% overall survival in chronic lymphocytic leukemia with Richter transformation, highlighting its efficacy.

Key Points

  • CAR T-cell therapy achieved a 61% overall survival rate after 12 months for patients with Richter transformation.
  • Among 28 patients treated, the one-month overall response rate was 75%, including a 54% complete response rate.
  • The cohort included patients with chronic lymphocytic leukemia-related aberrations, such as TP53 mutations in 46%.
  • Encouraging efficacy observed with manageable cytokine release syndrome and neurotoxicity levels suggests potential for broader application.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da56https://doi.org/10.1182/blood-2025-2779
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Real-world Australian experience with tisagenlecleucel for relapsed/refractory diffuse large B-cell lymphoma—importance of pre-CAR-T optimization2025 · 2 citations
  2. 2Real world chimeric antigen receptor T-cell therapy outcomes in T cell/histiocyte-rich large B-cell lymphoma: The Australian experience2025
  3. 3Immune exhaustion limits CD19 CAR-T efficacy in Richter's transformation2025
  4. 4A simple scoring system for response and toxicity following lymphoma CAR-T: Results from the Australian CAR-T real-world consortium2025 · 1 citations
  5. 5Efficacy and safety of chimeric antigen receptor (CAR) T-cell therapy in richter transformation: A systematic review and meta-analysis2025