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December 8, 2025Blood

Therapy-related AML (t-AML) on the rise: A national perspective on evolving trends, treatment outcomes, and prognostic implications in hospitalized patients

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Authors

PSPrakhyath Srikaram

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Overview

Retrospective cohort study reveals lower mortality and shorter hospital stays for t-AML patients, suggesting improved care.

Key Points

  • t-AML patients experienced lower in-hospital mortality at adjusted odds of 0.54, compared to de novo AML.
  • The analysis included 460,090 AML hospitalizations, with 164,750 identified as t-AML from 2016 to 2021.
  • Assessment using multivariable linear regression models identified trends in length of stay and hospital charges.
  • These findings highlight a shift in clinical outcomes for t-AML, warranting further prospective studies.

Cite This Study

Prakhyath Srikaram (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236da04https://doi.org/10.1182/blood-2025-5181
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