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December 8, 2025BloodOpen Access

B cell kinetics on next generation sequencing after CAR T-cell therapy in multiple myeloma

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Retrospective analysis detected hypogammaglobulinemia effects on patient outcomes post-CAR T-cell therapy.
A cohort of 37 patients with multiple myeloma maintained MRD negativity at high sensitivity within 100 days post-infusion.
Total B cell abundance and diversity metrics were calculated from sequencing data, uncovering important recovery signals.
Findings suggest NGS profiling may guide immune recovery monitoring following BCMA-directed CAR T therapy.

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Retrospective analysis shows hypogammaglobulinemia influences patient outcomes after CAR T-cell therapy, indicating future treatment considerations.

Puła et al. (2025) studied this question.

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Retrospective analysis shows hypogammaglobulinemia influences patient outcomes after CAR T-cell therapy, indicating future treatment considerations.