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December 8, 2025BloodOpen Access

Safety results from REALiTAL: A multi-country observational retrospective study of talquetamab in patients with relapsed/refractory multiple myeloma outside of clinical trials

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Authors

RPRakesh PopatKUKatarina UttervallAPAurore Perrot

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Overview

Observational study reported manageable adverse events in patients treated with talquetamab, suggesting its safety profile aligns with clinical trials.

Key Points

  • Overall tolerance of talquetamab was high, with manageable adverse events like cytokine release syndrome and infections.
  • Data from 93 patients over a median follow-up of 15 months demonstrated that most adverse events were grade 1/2.
  • Observational analysis across multiple countries highlighted efficacy alongside overall safety profile consistent with previous studies.
  • Significant resolution of toxicities suggests further investigation into talquetamab's long-term safety is warranted.

Cite This Study

Popat et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9cfhttps://doi.org/10.1182/blood-2025-4573
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