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December 8, 2025Blood

Central nervous system involvement in Mantle Cell Lymphoma: A retrospective multicenter cohort study from the spanish geltamo group

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Authors

ACAlba CabirtaAPA. Callejo PérezACAna Saus Carreres

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Overview

Retrospective cohort study reveals early CNS involvement decreases progression-free survival and overall survival in mantle cell lymphoma, suggesting need for targeted therapies.

Key Points

  • CNS involvement significantly lowers progression-free survival compared to patients without it, impacting clinical outcomes.
  • Patients with CNS invasion show a 5.2% incidence, highlighting critical challenges in managing mantle cell lymphoma.
  • Multivariate analysis identifies CNS involvement at diagnosis as a major adverse prognostic factor for both progression-free survival and overall survival.
  • Autologous stem cell transplantation does not improve survival outcomes for patients with CNS involvement in mantle cell lymphoma.

Cite This Study

Cabirta et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d9c8https://doi.org/10.1182/blood-2025-3585
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Secondary central nervous system lymphoma (SCNSL) in mantle cell lymphoma (MCL): Characteristics and risk factors in a Danish nationwide population-based study.2025
  2. 2Anti-CD19 CAR-T cells for Mantle Cell Lymphoma with central nervous system involvement: A study of the french descart registry.2025
  3. 3Real-world treatment and outcomes of Mantle Cell Lymphoma in Latin America: A multinational cohort analysis2025
  4. 4Real-world outcomes of Mantle Cell Lymphoma in Colombia: A multicenter cohort study2025
  5. 5Clinicopathologic Characteristics and Survival Outcome of Patients With Mantle Cell Lymphoma: A North Indian Tertiary Care Center Experience2025 · 1 citations