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December 8, 2025BloodOpen Access

Subtotal versus total splenectomy in children with sickle cell disease: Clinical outcomes and splenic function assessed by pocked red blood cell count

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Authors

VBValentine BrousseJBJoséphine BricePBPierre Buffet

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Overview

Retrospective study shows surgical procedure impacts clinical outcomes and vaso-occlusive crises in children with sickle cell disease.

Key Points

  • Subtotal splenectomy associates with higher early inflammatory events in children with sickle cell disease, compared to total splenectomy.
  • Patients experienced more vaso-occlusive crises and longer intensive care unit stays after subtotal splenectomy.
  • Surgical procedure choice influences the risk of postoperative complications and splenic function preservation.
  • Total splenectomy was linked to fewer early complications but does not ensure long-lasting splenic function.

Cite This Study

Brousse et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d997https://doi.org/10.1182/blood-2025-2953
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