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December 8, 2025Blood

Venetoclax-based therapy remodels T-cell and NK-cell immunity in patients with chronic lymphocytic leukemia

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Authors

AFAnna Maria FrustaciMVMarzia VarettoniMMMaria Chiara Montalbano

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Overview

Observational analysis revealed venetoclax alters T-cell and NK-cell subsets in chronic lymphocytic leukemia, suggesting a role in immune modulation.

Key Points

  • Venetoclax treatment reshapes T-cell and NK-cell immunity after one month.
  • CD3⁺ T-cell counts significantly declined; increase in terminally differentiated T cells noted at 6 months.
  • Analysis of immune checkpoint expression shows notable changes in CD4⁺ T-cells during treatment.
  • Results highlight potential for venetoclax to impact immune responses in chronic lymphocytic leukemia.

Cite This Study

Frustaci et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d8a7https://doi.org/10.1182/blood-2025-5657
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune reconstitution after venetoclax-based treatments in CLL2025
  2. 2Long-term immune reconstitution and final 1-year follow-up after fixed-duration venetoclax-obinutuzumab (VenO) in first-line (1L) chronic lymphocytic leukemia (CLL): Results from the Phase III CRISTALLO trial2025
  3. 3Efficacy of fixed-duration venetoclax-based regimens as first-line in chronic lymphocytic leukemia: A systematic review and meta-analysis of clinical trials2025
  4. 4Clinical experience and safety of venetoclax in the treatment of patients with chronic lymphocytic leukemia in second and subsequent lines of therapy: Real-world data fron hemato-oncology centers  of slovakia2025
  5. 5Venetoclax-obinutuzumab in frontline and R/R CLL: Outcomes compared to age- and sex-matched general population2025