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December 8, 2025Blood

Prognostic impact of pre-transplant IPSS-m risk downstaging in Myelodysplastic Syndromes

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Authors

ASAsmita ShuklaSCSikander ChohanNYNagasai Yalavarthi

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Overview

Analysis reveals downstaging improves overall survival and relapse-free survival in MDS, suggesting dynamic risk assessment is crucial.

Key Points

  • Downstaging of IPSS-M scores links to significantly improved median overall survival outcomes, highlighting its prognostic value.
  • Patients experiencing downstaging showed a median overall survival of 64 months compared to 22 months for other groups.
  • Assessment via a 54-gene TruSight Myeloid Panel indicates potential shifts in karyotype and genetic mutations in MDS.
  • Findings suggest that using IPSS-M as a dynamic tool can better reflect treatment responses before transplant.

Cite This Study

Shukla et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d85dhttps://doi.org/10.1182/blood-2025-3872
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impacts of IPSS-m and conditioning intensity in allogeneic hematopoietic cell transplant for patients with myelodysplasia neoplasms2025
  2. 2Upfront vs posttherapy allogeneic stem cell transplantation for high-risk myelodysplastic syndrome – a real-world analysis in the era of molecular risk stratification2025
  3. 3Integrated machine learning-based prognostic models for patients with Myelodysplastic Syndromes/neoplasms (MDS)2025
  4. 4Comparative Analysis of IPSS, IPSS-R, and WPSS for Predicting Survival and Leukemic Transformation in Myelodysplastic Neoplasms: A Real-World Single-Center Experience.2025
  5. 5IPSS-m outperforms IPSS-R in younger adults with Myelodysplastic Syndromes: A retrospective age-stratified analysis2025