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December 8, 2025BloodOpen Access

Short-term and long-term sting activation elicit divergent cellular responses in distinct hematopoietic populations in chronic myelomonocytic leukemia

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Authors

YWYue WeiZLZiyi LiKLK. J. Linthicum

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Overview

Evaluation of short- and long-term STING effects reveals CCR2+ monocyte depletion and apoptosis in hematopoietic populations.

Key Points

  • STING activation induces significant CCR2+ monocyte apoptosis in chronic myelomonocytic leukemia models, highlighting its potential therapeutic role.
  • Single-cell RNA-sequencing confirmed that short-term STING activation depletes monocyte populations and alters inflammatory gene expression.
  • Hematopoietic stem-cell and monocyte responses to STING activation differ significantly, depending on activation duration.
  • Long-term STING exposure showed less impact on cell populations, indicating adaptive mechanisms to inflammatory stress.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d83bhttps://doi.org/10.1182/blood-2025-3832
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1DIFFERENTIAL STING ACTIVATION IN DENDRITIC CELLS SHAPES DISTINCT CD4 T CELL RESPONSES AND OPPOSING COLITIS OUTCOMES2026
  2. 2ST2 promotes leukemia transformation by reshaping the immune landscape in Acute Myeloid Leukemia2025
  3. 3Loss of serine threonine protein kinase 25 (STK25) in the bone marrow niche attenuates g/CSF- and TLR7-induced emergency myelopoiesis and mobilization into the periphery2025
  4. 4High dose ascorbate downregulates innate immune cytokines in the bone marrow of TET2 mutant chronic myelomonocytic leukemia2025
  5. 5Impact of innate immune memory on MDS progression by TET2-driven inflammation2025