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December 8, 2025BloodOpen Access

Short-term and long-term sting activation elicit divergent cellular responses in distinct hematopoietic populations in chronic myelomonocytic leukemia

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Authors

YWYue WeiZLZiyi LiKLK. J. Linthicum

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Overview

Evaluation of short- and long-term STING effects reveals CCR2+ monocyte depletion and apoptosis in hematopoietic populations.

Key Points

  • STING activation induces significant CCR2+ monocyte apoptosis in chronic myelomonocytic leukemia models, highlighting its potential therapeutic role.
  • Single-cell RNA-sequencing confirmed that short-term STING activation depletes monocyte populations and alters inflammatory gene expression.
  • Hematopoietic stem-cell and monocyte responses to STING activation differ significantly, depending on activation duration.
  • Long-term STING exposure showed less impact on cell populations, indicating adaptive mechanisms to inflammatory stress.

Cite This Study

Wei et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d83bhttps://doi.org/10.1182/blood-2025-3832
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