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December 8, 2025BloodOpen Access

Cytogenetic testing in newly diagnosed multiple myeloma (NDMM): Real world evidence of adverse outcomes for high risk groups.

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Authors

GZGhassan ZammarRRRajeev RajagopalEWErica M. Wood

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Overview

Analysis reveals associations between high-risk cytogenetic abnormalities and poorer overall survival in newly diagnosed multiple myeloma patients.

Key Points

  • Increasing HRCA burden leads to distinct disease characteristics, influencing treatment outcomes significantly.
  • Patients with higher lactate dehydrogenase and β2-microglobulin levels present more frequently with anaemia and bone disease.
  • Progression-free survival decreases with the rising number of HRCA, correlating to overall survival rates.
  • Results suggest specific monitoring for those with del(17p) due to its strong association with poorer prognosis.

Cite This Study

Zammar et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7c9https://doi.org/10.1182/blood-2025-2221
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cytogenetics-based clinical trajectories of patients with MRD negativity post autologous stem cell transplant for multiple myeloma2025
  2. 2Characterization of NDMM patients treated with daratumumab, lenalidomide, bortezomib and dexamethasone who fail to achieve a VGPR or have early progression2025
  3. 3Patterns of minimal residual disease trajectories in 323 newly diagnosed patients with multiple myeloma and correlation with progression-free survival2025
  4. 4Validation and refinement of the new high-risk multiple myeloma (HRMM) criteria in relapsed or refractory patients treated with BCMA CAR-T.2025
  5. 5Prognostic significance of 1q21 gain/amplification and co-existing cytogenetic abnormalities in Chinese patients with newly diagnosed multiple myeloma2025