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December 8, 2025BloodOpen Access

Transcriptomic signatures associated with deep molecular response to ropeginterferon alfa-2b in polycythemia vera

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Authors

SYSung-Soo YoonDYDeok‐Hwan YangSSSang Kyun Sohn

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Overview

Prospective analysis shows ropeginterferon alfa-2b improves molecular response in polycythemia vera, indicating immune activation is key for therapeutic outcomes.

Key Points

  • At week 132, 31 patients achieved deep molecular response defined by allele burden <2%.
  • Overall, 88.9% of patients reached molecular response as per ELN 2009 criteria, indicating efficacy of ropeginterferon.
  • Analysis includes RNA sequencing to assess transcriptomic features correlated with treatment efficacy in polycythemia vera patients.
  • Findings emphasize the importance of immune activation pathways in evaluating molecular responses for future assessments.

Cite This Study

Yoon et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d788https://doi.org/10.1182/blood-2025-2040
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