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December 8, 2025Blood

Wildtype NUP98 cooperates with NPM1c to drive oncogenic transcription

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Authors

SGSara GamaMMMarcel MüllerHDHannah González Dammers

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Overview

Observed chromatin binding of NUP98 and NPM1c in acute myeloid leukemia, indicating NUP98's role in regulating gene expression.

Key Points

  • NUP98 is essential for the transcriptional regulation of oncogenic target genes in acute myeloid leukemia.
  • Mass spectrometric analysis identified nucleoporins as significant components of NPM1c's interactome.
  • CRISPR gene editing demonstrated that NUP98 depletion enhances apoptosis and differentiation in myeloid leukemia cells.
  • The study indicates a potential subtype-specific role of NUP98 in the regulation of gene expression in leukemogenesis.

Cite This Study

Gama et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d757https://doi.org/10.1182/blood-2025-865
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Disrupting the PA2G4-NPM1 axis induces nucleolar stress in NPM1c AML2025
  2. 2Inhibition of nucleoporin 214 depletes leukemia stem cells by promoting heme catabolism and lipid peroxidation2026
  3. 3NUP98-rearranged pediatric AML is sustained by a conserved leukemia stem cell program with SPNS2/3 as a targetable vulnerability2025
  4. 4Strategies for identifying <i>NUP98</i> rearrangements in adult myeloid neoplasms2025 · 1 citations
  5. 5A Comprehensive Genomic Analysis of Nucleophosmin (NPM1) in Acute Myeloid Leukemia2025 · 2 citations