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December 8, 2025BloodOpen Access

Shared immune features correspond to high-risk multiple myeloma across multiple human subtypes and murine models

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Authors

FNFnu NabuqiTMTarek H. MouhieddineKCKiana L. Chen

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Overview

Observational analysis identifies immune features and TME changes in high-risk multiple myeloma, suggesting targets for intervention.

Key Points

  • High-risk multiple myeloma is associated with distinct immune changes, including increased monocytes and activated CD8+ T cells.
  • The study reveals that TP53 loss influences the tumor micro-environment and promotes macrophage re-programming in aggressive cases.
  • Integrated analysis of patient samples and murine models clarifies the role of immune programs in disease progression.
  • These findings highlight potential therapeutic targets to improve outcomes in high-risk multiple myeloma patients.

Cite This Study

Nabuqi et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6d9https://doi.org/10.1182/blood-2025-5723
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