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December 8, 2025BloodOpen Access

High-frequency monitoring of clonal dynamics in MPN using saliva and peripheral blood during interferon therapy

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Authors

BSBrian J. SworderNPNicholas R. Pannunzio

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Overview

Retrospective and longitudinal analysis reveals molecular responses to interferon therapy in MPN, suggesting predictive biomarker potential.

Key Points

  • JAK2V617F variant allele frequency kinetics demonstrate predictive value in monitoring response to interferon therapy.
  • Among 62 MPN patients, only 23% showing hematologic remission had over 50% reduction in JAK2V617F VAF.
  • Observational analysis of saliva and blood samples assessed clonal dynamics during interferon treatment.
  • Early VAF elevation may indicate biologically productive clonal cycling, supporting targeted therapy adjustments.

Cite This Study

Sworder et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6adhttps://doi.org/10.1182/blood-2025-7268
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