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December 8, 2025BloodOpen Access

Talquetamab induces deep responses in heavily pre-treated patients with systemic light-chain amyloidosis

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Authors

MGMohammed GanayemIAIrit Avivi

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Overview

A case series demonstrates significant hematologic responses in relapsed AL amyloidosis patients, suggesting talquetamab's potential as a treatment option.

Key Points

  • 83% of patients achieved hematologic response with talquetamab treatment, indicating strong efficacy in a difficult-to-treat population.
  • Talquetamab was given to patients with advanced organ dysfunction, showing promise as a feasible treatment option.
  • Retrospective analysis across multiple sites evaluated safety and efficacy in relapsed or refractory AL amyloidosis patients.
  • The safety profile was manageable, with no unexpected toxicities observed following treatment.

Cite This Study

Ganayem et al. (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d6a5https://doi.org/10.1182/blood-2025-7491
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