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December 8, 2025BloodOpen Access

CAR-T cell therapy in multiple myeloma in a front-line setting: A systematic review and meta-analysis

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Authors

MSMoazzam Shahzad

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Overview

Systematic review shows CAR-T therapy yields 90% complete response in multiple myeloma, indicating potential for improved patient outcomes.

Key Points

  • Complete response reached 90% in newly diagnosed multiple myeloma patients following CAR-T treatment, showing significant efficacy.
  • Pooled data from four studies included a total of 81 patients aged 43 to 73 with initial treatment regimens involving various combinations.
  • Meta-analysis used random-effects modeling to derive results for response rates and complications in CAR-T therapy for myeloma.
  • The findings suggest that CAR-T therapy may provide durable responses, but larger trials are needed to affirm these promising outcomes.

Cite This Study

Moazzam Shahzad (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d621https://doi.org/10.1182/blood-2025-7605
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CAR-T cells manufactured after multiple myeloma triplet or quadruplet induction therapy have reduced functionality and an altered composition2025
  2. 2Comparison of clinical outcomes in multiple myeloma patients treated with chimeric antigen receptor (CAR)-T cell therapy across clinical trials: Intention-to-treat vs. per-protocol analyses2025
  3. 3Real-world comparison of CAR T-cell therapy versus bispecific antibodies in relapsed or refractory multiple myeloma2025 · 1 citations
  4. 4BCMA-CART therapy in 29 cases of relapsed or refractory multiple myeloma:a retrospective study2025
  5. 5Comparative efficacy and safety of BCMA-targeted CAR T cells and BiTEs in relapsed/refractory multiple myeloma: a meta-analysis of interventional and real-world studies2025 · 10 citations