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December 8, 2025BloodOpen Access

Cyclin D1 beyond the cell cycle: A new role in t(11;14) multiple myeloma

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Authors

SSSuganti ShivaramRFRafaël FonsecaEBEsteban Braggio

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Overview

Investigation reveals cyclin D1 influences gene regulation and metabolic plasticity in t(11;14) multiple myeloma.

Key Points

  • Transcriptional regulation is significantly altered in t(11;14) multiple myeloma cases due to cyclin D1 involvement.
  • Metabolomic assessment showed that cyclin D1 KO affected cell growth and urea cycle function significantly.
  • Analysis utilized RNA-seq, ATAC-seq, and ChIP-seq to investigate the epigenomic impacts of cyclin D1.
  • Findings indicate that cyclin D1 represents a potential therapeutic target in managing multiple myeloma.

Cite This Study

Shivaram et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5f3https://doi.org/10.1182/blood-2025-3939
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NSD2 expression remodels DNA methylation, creating a targetable epigenetic dependency in t(4;14) multiple myeloma2025
  2. 2NSD2 inhibition suppresses t(4;14) gene expression and oncogenic signaling to impair proliferation in multiple myeloma2025
  3. 3Disruption of NEAT1-transcriptional network identifies targetable non-genetic dependencies in multiple myeloma2025
  4. 4Revealing oncogenic enhancer regulation by epigenomic profiling of multiple myeloma and plasma cell leukemia patient samples2025
  5. 5SKP2/CKS1B as a rational drug target in 1q21 amplified multiple myeloma.2025