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December 8, 2025BloodOpen Access

Activation effects of chidamide on BET signaling pathways and the mechanism of  synergistic effect with BET inhibitors in Mantle Cell Lymphoma

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Authors

LFLi FuJSJing Shen

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Overview

Proteomic analysis shows chidamide reduces HDAC1 and enhances cytotoxicity in mantle cell lymphoma, suggesting potential dual therapy benefits.

Key Points

  • Chidamide reduces the expression of HDAC1 in mantle cell lymphoma, enhancing its therapeutic efficacy.
  • IC50 for chidamide was measured at 0.9 μM, highlighting its potent effect over time in MCL cells.
  • Cytotoxicity studies and cell cycle arrest evaluation revealed synergistic effects with BET inhibitors.
  • Further studies are needed to explore mechanisms involving the immune microenvironment and tumor-associated macrophages.

Cite This Study

Fu et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5cahttps://doi.org/10.1182/blood-2025-7053
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Also Consider

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  1. 1Chidamide reprograms AML-associated macrophages via HDAC3 inhibition to boost CD8+ T cell immunity2025
  2. 2Synergistic effects of histone deacetylase inhibitor chidamide and BCL-2 inhibitor venetoclax in activating the p53 pathway in diffuse large B-cell lymphoma2025
  3. 3Chidamide and anlotinib synergistically inhibit high grade B-cell lymphomas via PI3K/AKT signaling pathway2025
  4. 4Low-dose chidamide maintenance therapy following allogeneic hematopoietic stem cell transplantation in T-cell acute lymphoblastic leukemia or lymphoma: A phase 2, open-label, multicenter, single-arm trial2025
  5. 5HDAC inhibitors potentiate the efficacy of antineoplastic agents in acute megakaryoblastic leukemia via dual activation of apoptosis and pyroptosis2025