Synapse
⌘+K
Synapse
PulseExploreJournal ClubResearchersJournals
Instagram
HomeJournal ClubExplore
December 8, 2025BloodOpen Access

Absolute lymphocyte count is predictive of response to salvage therapies for post-CAR T failure

View Full Paper
Ask AI
Bookmark
Share

Authors

HAHazim AbabnehANAndrea NgMFMatthew Frigault

Discussion

Loading...

Member takes

Overview

Retrospective analysis shows higher absolute lymphocyte count predicts improved survival in large B-cell lymphoma, indicating its role as a biomarker for therapeutic strategies.

Key Points

  • Improved progression-free survival is associated with lymphocyte counts above 1.0 x 10⁹/L in large B-cell lymphoma patients.
  • Analysis of median overall survival revealed key metrics linked to lymphocyte count post-salvage therapies.
  • Retrospective study included 352 large B-cell lymphoma patients receiving CAR T therapy and subsequent salvage treatments.
  • Findings highlight risk stratification and treatment outcomes, underscoring the potential for lymphocyte count in patient management.

Cite This Study

Ababneh et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d584https://doi.org/10.1182/blood-2025-1928
View Full Paper
Ask AI
Bookmark
Share