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December 8, 2025BloodOpen Access

MRD-guided azacitidine maintenance improves outcomes in molecularly persistent pediatric core-binding factor AML: A retrospective cohort study

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Authors

YCYiqiao Chen

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Overview

Retrospective cohort study shows azacitidine maintenance improves outcomes in pediatric AML, suggesting MRD strategies reduce relapse.

Key Points

  • Azacitidine maintenance therapy achieved comparable outcomes in disease-free survival and overall survival compared to observation.
  • At 34.6-month median follow-up, azacitidine showed improved DFS in intermediate-risk patients and sustained MRD negativity.
  • Retrospective cohort study of 78 pediatric AML patients evaluated outcomes after azacitidine versus observation.
  • Findings highlight potential benefits of MRD-guided maintenance strategies to reduce relapse in pediatric AML subgroups.

Cite This Study

Yiqiao Chen (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d54dhttps://doi.org/10.1182/blood-2025-7050
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