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December 8, 2025Blood

Risk of bleeding in chronic lymphocytic leukemia patients in remission treated with covalent Bruton tyrosine kinase inhibitors and contemporary anticoagulant or antiplatelet drugs: Real-world data analysis

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Authors

HCHeidi ChoPAREXEL International (United Kingdom)CLChris A. LearnPAREXEL International (United Kingdom)

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Implication

Real-world data analysis shows increased bleeding risk in CLL patients treated with BTK inhibitors and anticoagulant therapy, suggesting careful management is needed.

Key Points

Patients with chronic lymphocytic leukemia experienced significantly higher bleeding risk when treated with BTK inhibitors alongside anticoagulants.
Over three years, the bleeding rate for patients on BTK inhibitors and anticoagulants was 35.2%, compared to 23.2% for those on BTK inhibitors only.
Analysis included real-world data from multiple centers with a focus on bleeding events identified using ICD-10 codes.
Findings highlight the importance of evaluating treatment outcomes and clinical practice guidelines for anticoagulant use in this patient group.

Cite This Study

Cho et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d546 https://doi.org/10.1182/blood-2025-6315

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Implication

Real-world data analysis shows increased bleeding risk in CLL patients treated with BTK inhibitors and anticoagulant therapy, suggesting careful management is needed.

Risk of bleeding in chronic lymphocytic leukemia patients in remission treated with covalent Bruton tyrosine kinase inhibitors and contemporary anticoagulant or antiplatelet drugs: Real-world data analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

Risk of bleeding in chronic lymphocytic leukemia patients in remission treated with covalent Bruton tyrosine kinase inhibitors and contemporary anticoagulant or antiplatelet drugs: Real-world data analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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