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December 8, 2025BloodOpen Access

Epidemiological survey of familial myelodysplastic syndromes/acute myeloid leukemia in Hawaii

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Authors

MTManasawee TanariyakulAMAkihiro MiyashitaDCDominic C. Chow

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Overview

Retrospective analysis reveals low familial MDS/AML rates among Native Hawaiians, suggesting genetic variability.

Key Points

  • The median overall survival rate for familial myelodysplastic syndromes was 12.7 years, highlighting their significant longevity.
  • Among MDS/AML patients, only 0.71% had familial MDS/AML, indicating potential genetic determinants.
  • Next-generation sequencing showed DNMT3A mutations in familial cases, suggesting their role in genetic profiles.
  • Variability in disease characteristics calls for further research into the genetic heterogeneity of MDS and AML.

Cite This Study

Tanariyakul et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d530https://doi.org/10.1182/blood-2025-7396
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