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December 8, 2025BloodOpen Access

Outcomes with repeat CAR-t cell therapy: A systematic review and meta-analysis

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Authors

AUAman Ullah

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Overview

Meta-analysis reports a 55% overall response in patients receiving repeat CAR-T therapy, indicating ongoing need for effective treatments.

Key Points

  • Repeat CAR-T therapy achieved an overall response rate of 55%, showing potential for relapsed cases.
  • Patients included evaluations from three retrospective studies and one Phase I trial, indicating a comprehensive analysis approach.
  • Statistical analyses employed both random and fixed effects models, providing detailed insights into response rates and outcomes.
  • Generally, CART2 yielded lower response rates compared to CART1, highlighting the need for further research and trials.

Cite This Study

Aman Ullah (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4fchttps://doi.org/10.1182/blood-2025-7632
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Also Consider

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  1. 1Safety and efficacy of anti-CD19 chimeric antigen receptor (CAR) T-cell therapy in relapsed or refractory B-cell lymphomas: A systematic review and meta-analysis2025
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  3. 3Real-world outcomes of autologous CD19-directed CAR T-cell therapy in relapsed/refractory large B-cell lymphoma: A single-center experience2025 · 1 citations
  4. 4Human CART22.19 therapy in refractory pediatric B-ALL: insights from a named-patient cohort2026
  5. 5Large B-cell lymphoma following CD19-directed CART-cell therapy failure: Impact of CAR construct on disease features and outcomes of subsequent therapies2025