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December 8, 2025BloodOpen Access

Iron infusions in pregnant women are associated with comparable efficacy and safety compared to non-pregnant women

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Authors

SFSteven FeinDADayne AlonsoALAdam K. Lewkowitz

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Overview

Observational analysis shows iron infusions are similarly effective and safe for pregnant women and non-pregnant women, suggesting comparable tolerability and symptom relief.

Key Points

  • Iron infusions effectively increased hemoglobin in pregnant women by 1.2g/dL and 1.8g/dL in non-pregnant women.
  • Safety analysis revealed infusion reactions in 3.3% of pregnant women, similar to 3.5% in non-pregnant women.
  • Pregnant women reported slightly more post-infusion discomfort symptoms at 16.6% compared to 8.5% in non-pregnant women.
  • Tolerability of iron infusions is overall consistent across both groups, indicating benefits exceed risks for pregnant women.

Cite This Study

Fein et al. (2025) studied this question.

synapsesocial.com/papers/69362f3d4fa91c937236d4d6https://doi.org/10.1182/blood-2025-4477
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