December 8, 2025BloodOpen Access

Therapy-induced senescence reprograms non-M3 AML into a drug-exploitable APL-like state

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Therapy-induced senescence fosters an APL-like phenotype in acute myeloid leukemias, suggesting new treatment strategies.

Therapy-induced senescence reprograms non-M3 acute myeloid leukemias into a drug-exploitable APL-like state, enhancing treatment responses.
Acute myeloid leukemias show drug-exploitable vulnerabilities linked to cellular senescence and distinct transcriptomes.
Multi-omic analyses reveal how therapy-induced senescence affects treatment outcomes through epigenetic changes.
This highlights the potential for novel therapies targeting senescence-induced plasticity in malignancies.

Schönlein et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

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Authors

Therapy-induced senescence fosters an APL-like phenotype in acute myeloid leukemias, suggesting new treatment strategies.

Therapy-induced senescence reprograms non-M3 acute myeloid leukemias into a drug-exploitable APL-like state, enhancing treatment responses.
Acute myeloid leukemias show drug-exploitable vulnerabilities linked to cellular senescence and distinct transcriptomes.
Multi-omic analyses reveal how therapy-induced senescence affects treatment outcomes through epigenetic changes.
This highlights the potential for novel therapies targeting senescence-induced plasticity in malignancies.

Schönlein et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark