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December 8, 2025BloodOpen Access

Non-hematotoxic Tim-3/CD70 dual-targeting CAR T cells promote potent anti-leukemia activity against acute myeloid leukemia

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Authors

KSKang‐Yi SuLRLee RyanAMAlyssa Massa

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Overview

Dual-targeting CAR T cells improved cytotoxicity and reduced T cell exhaustion in acute myeloid leukemia models, suggesting a safer therapeutic approach.

Key Points

  • Dual-targeting CAR T cells effectively eliminate leukemia cells expressing low antigen levels, enhancing treatment efficacy.
  • Immunophenotyping identifies higher Tim-3 and CD70 expression in leukemic stem cells versus healthy controls, validating targeting strategy.
  • Immunophenotyping shows enhanced expansion and persistence of dual-CAR T cells compared to single-CAR T cells, supporting their potential in therapy.
  • No sustained hematotoxicity or organ damage observed, indicating favorable safety for dual-targeting strategy in acute myeloid leukemia.

Cite This Study

Su et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d466https://doi.org/10.1182/blood-2025-2345
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bicistronic CAR T-cells Against CD70 & Active Integrin β2 Overcome Antigen Heterogeneity and Preserve Safety in Acute Myeloid Leukemia2025
  2. 2A novel B7-H3-specific binder enables effective CAR T-cell therapy in an Acute Myeloid Leukemia experimental model2025
  3. 3CRISPR/Cas9-engineered universal CD123/B7-H3 tandem CAR-T cell for the treatment of acute myeloid leukemia2025 · 3 citations
  4. 4Interpreting the clinical outcomes to date for AML-directed CAR T cell therapies2025 · 1 citations
  5. 5CAR-T cells in hematologic disorders: acute myeloid leukemia - A systematic review of efficacy and safety2025 · 1 citations