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December 8, 2025Blood

Single-cell profiling reveals teclistamab-induced reshaping of nasopharyngeal immunity in multiple myeloma

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Authors

TKTobias KrammerNANazia AfrinKKK. Martin Kortüm

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Overview

Single-cell RNA sequencing demonstrates significant immune cell alterations in the nasopharynx of multiple myeloma patients treated with teclistamab, suggesting impacts on respiratory infections.

Key Points

  • A loss of immune cells in the nasopharynx was observed in multiple myeloma patients treated with teclistamab.
  • Single-cell RNA sequencing revealed significant changes in immune cell populations and gene expression in the nasal microenvironment.
  • Patients showed a lack of dendritic cells and monocytes compared to healthy individuals, indicating compromised local immunity.
  • Altered nasopharyngeal immunity may explain persistent respiratory infections in treated patients, highlighting a need for intervention.

Cite This Study

Krammer et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3f9https://doi.org/10.1182/blood-2025-5698
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The resistec study: Dissecting immune correlates of resistance and response to teclistamab in real-world multiple myeloma2025
  2. 2Real-world analysis of infection timing and burden in multiple myeloma patients treated with teclistamab2025
  3. 3Real-world outcomes of teclistamab in triple-exposed relapsed/refractory multiple myeloma: Brazilian single-center experience2025
  4. 4Real-world efficacy and safety of teclistamab in relapsed or refractory multiple myeloma: Results from 87 patients treated by the polish myeloma group2025
  5. 5Low-dose teclistamab in newly diagnosed multiple myeloma patients2025 · 1 citations