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December 8, 2025BloodOpen Access

Transfusion dependence is associated with poor survival in MDS-h and MDS-LB, while transplantation improves outcomes

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Authors

HWHui WangEJErlie JiangZXZhijian Xiao

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Overview

Retrospective analysis shows transplantation improves long-term outcomes in transfusion-dependent MDS patients, suggesting better care strategies.

Key Points

  • Survival is significantly improved with transplantation among transfusion-dependent patients.
  • Cumulative incidence of transfusion dependence during follow-up was 45.56% among initially independent patients.
  • Assessment of cytopenias and disease burden revealed distinct profiles in MDS-h versus MDS-LB subtypes.
  • Risk classification reflects critical prognostic factors for overall survival and disease progression.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3f5https://doi.org/10.1182/blood-2025-7381
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