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December 8, 2025BloodOpen Access

LILRB4 drives proinflammatory cytokine secretion in multiple myeloma to promote the immune-cell dysfunction via the generation of myeloid-derived suppressive cells

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Authors

YWYijie Wang

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Overview

Observational analysis reveals LILRB4 drives myeloid-derived suppressive cells and immune dysfunction in multiple myeloma, suggesting significant disease implications.

Key Points

  • LILRB4 expression increases proinflammatory cytokine levels, driving immune dysfunction in multiple myeloma.
  • Single-cell RNA sequencing identified LILRB4 as a key regulator of myeloid-derived suppressive cells in bone marrow.
  • Analysis shows that elevated levels of CCL3 contribute to immune suppression and poor outcomes in multiple myeloma.
  • The findings highlight that LILRB4 exacerbates tumor microenvironment effects, indicating a need for targeted therapies.

Cite This Study

Yijie Wang (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3e2https://doi.org/10.1182/blood-2025-5695
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