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December 8, 2025BloodOpen Access

Refined genetic risk model with complex karyotype predicts outcomes of newly diagnosed acute myeloid leukemia treated with decitabine plus venetoclax

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Authors

RMRazan MohtyMHMaris HardeeMEManuel Espinoza-Gutarra

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Overview

Observational study shows predictive ability of a refined genetic risk model in acute myeloid leukemia, indicating improved outcomes with decitabine and venetoclax treatment.

Key Points

  • mELN2024 model demonstrated superior predictive ability for overall survival compared to the ELN2022 and ELN2024 models.
  • Patients with TP53 mutations showed a significant relationship with improved relapse-free survival and overall survival.
  • Univariate and multivariate Cox regression analyses employed to assess baseline characteristics in terms of survival outcomes.
  • Cytogenetics maintained critical prognostic significance for survival in patients treated with decitabine plus venetoclax.

Cite This Study

Mohty et al. (2025) studied this question.

synapsesocial.com/papers/69362f3a4fa91c937236d3b3https://doi.org/10.1182/blood-2025-5272
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prognostic evaluation of ELN-2022 and ELN-2024 risk stratification in newly diagnosed AML patients and development of a novel genetic risk model2025
  2. 2Risk stratification of newly diagnosed AML receiving nonintensive treatment2025
  3. 3Molecular predictors of survival in patients with myeloproliferative neoplasm-blast Phase (MPN-BP) treated with venetoclax and decitabine2025 · 1 citations
  4. 4Genetic risk stratification in adults with AML receiving venetoclax-based intensive therapy: A real-world study2025
  5. 5Performance of the ELN 2022 risk stratification in a real-world Canadian AML patient population2025