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December 8, 2025BloodOpen Access

Single-cell transcriptomics reveals proliferative, immune-evasive, and bone marrow–independent transcriptional programs in extramedullary multiple myeloma.

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Authors

MBMoritz Binder

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Overview

Single-cell RNA sequencing reveals unique transcriptional programs in extramedullary multiple myeloma, suggesting immune evasion and enhanced angiogenesis.

Key Points

  • Extramedullary multiple myeloma was found to exhibit a highly proliferative immune suppressive state.
  • Analysis included 128,908 clonal plasma cells from 16 samples, uncovering distinct transcriptional clusters.
  • Assessment using single-cell RNA sequencing revealed significant upregulation of angio-genesis and cell cycle pathways.
  • Findings indicate a critical need for deeper insights into immune signaling and metabolic reprogramming in EMD.

Cite This Study

Moritz Binder (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d386https://doi.org/10.1182/blood-2025-3940
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Spatially resolved transcriptomics reveals immunosuppressive niches and clonal diversity in extramedullary disease in multiple myeloma refractory to immunotherapy2025
  2. 2Genomic and transcriptomic signatures of extramedullary multiple myeloma reveal possible drivers of therapeutic resistance2025
  3. 3Multimodal assessment of chronic myelomonocytic leukemia with extramedullary involvement reveals RAS pathway activation, adverse outcomes and epithelial-mesenchymal transition2025 · 2 citations
  4. 4Multi-omics reveals immune features in immune and non-immune cells, an IFN-γ/IFN-α-B2M positive feedback loop, and targeted metabolic therapy in multiple myeloma2025
  5. 5Relationship between myeloma cell genomic alternations and tumor immune microenvironment in bone-related extramedullary disease of newly diagnosed multiple myeloma2025