Real world epidemiological trends in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), England 2014-2021: Preliminary data from the uncover Study group
Analysis reveals increased blood cancer incidence and relative survival trends in patients with NLPHL, highlighting geographical disparities and comorbidity impacts.
Key Points
To investigate the epidemiological trends and survival outcomes associated with nodular lymphocyte predominant Hodgkin lymphoma in England from 2014 to 2021.
Utilized the National Cancer Registration Dataset for patients diagnosed with blood cancer.
Calculated crude and age-standardised incidence rates along with incidence rate ratios using Poisson regression.
Estimated overall and relative survival using Kaplan–Meier and Cox regression models.
Registered 1648 NLPHL patients; median age at diagnosis was 49 years.
Overall age-standardised incidence rate was 0.39 per 100,000 persons/year, with higher rates seen in males and certain ethnic groups.
Five-year overall survival and relative survival rates exceeded 90%, but older age and comorbid conditions negatively impacted survival.