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December 8, 2025BloodOpen Access

TADA1 plays a regulatory role in erythropoiesis and the expression of HBG.

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Authors

DHDawei HuoRWRui WenHHHe Huang

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Overview

Genome-wide CRISPR-Cas9 screen identifies TADA1's role in fetal hemoglobin and erythroid differentiation, suggesting new therapeutic targets for sickle cell anemia.

Key Points

  • Investigate the regulatory role of TADA1 in erythropoiesis and HBG expression.
  • Conducted a genome-wide CRISPR-Cas9 screen
  • Validated findings in HUDEP2 cells and primary CD34+ hematopoietic stem cells
  • Analyzed transcriptomic data from adult bone marrow and erythroid differentiation samples
  • TADA1 knockout increased HbF-positive cells and γ-globin expression
  • TADA1 is highly expressed in early erythroid progenitors
  • TADA1 regulates key transcription factors and ribosomal translation proteins, enhancing erythroid differentiation

Cite This Study

Huo et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2f8https://doi.org/10.1182/blood-2025-730
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structure guided targeting of the GATAD2A-CHD4 interaction in the MBD2-NuRD complex results in high levels of HbF2025
  2. 2A genome-wide CRISPR activation screen identifies novel γ-globin regulators2025
  3. 3Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer2026
  4. 4Stag2 dependent chromatin remodeling enforces the erythroid-specific Gata1 cistrome2025
  5. 5Silencing of BCL11A by disrupting enhancer-dependent epigenetic insulation2025 · 1 citations