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This research aims to analyze compensatory mutations in RNAP genes of multidrug resistant strains of Mycobacterium tuberculosis.

December 8, 2025PLoS ONEOpen Access

Patterns of compensatory mutations in rpoA/B/C genes of multidrug resistant M. tuberculosis in Uganda

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Analysis shows patterns of mutations in multidrug resistant Mycobacterium tuberculosis, indicating implications for transmission.

This research aims to analyze compensatory mutations in RNAP genes of multidrug resistant strains of Mycobacterium tuberculosis.
Conducted whole genome sequencing and Sanger DNA sequencing on 52 clinical isolates of Mycobacterium tuberculosis.
Included analysis of 32 multidrug resistant and 20 drug-susceptible isolates.
Identified mutations in the rpoB gene and other RNAP encoding genes.
24 out of 32 MDR-TB isolates had mutations in the rpoB rifampicin-resistance-determining region.
Identified multiple compensatory mutations in RNAP genes, particularly in rpoC.
Compensatory mutations were prevalent in MDR-TB clinical isolates, with specific patterns indicating potential impact on transmission.

Namakula et al. (2025) studied this question.

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