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December 8, 2025BloodOpen Access

Characterization of antecedent clonal hematopoiesis (CH) mutations in lymphoid and plasma cell neoplasms

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Authors

PDPinkal DesaiWLWodan LingMBMichal Bar‐Natan

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Overview

Large-scale analysis shows clonal hematopoiesis raises chronic lymphocytic leukemia risk, suggesting new detection strategies.

Key Points

  • This research aims to explore the relationship between antecedent clonal hematopoiesis and the risk of lymphoid and plasma cell neoplasms.
  • Targeted deep sequencing of 146 lymphoid and myeloid genes in 1200 samples from the Women's Health Initiative cohort.
  • Cases included individuals diagnosed with chronic lymphocytic leukemia, multiple myeloma, and diffuse large B cell lymphoma with prior blood samples.
  • Logistic regression and Firth logistic regression were used to analyze mutations and calculate odds ratios for disease associations.
  • Clonal hematopoiesis was significantly associated with increased odds of chronic lymphocytic leukemia (aOR 2.42, p<0.001).
  • Lymphoid-only clonal hematopoiesis showed the highest risk for chronic lymphocytic leukemia (aOR 3.08, p<0.001).
  • Specific mutations like BIRC6 and IGLL5 were identified as significant risk factors for chronic lymphocytic leukemia.

Cite This Study

Desai et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d245https://doi.org/10.1182/blood-2025-1399
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