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December 8, 2025BloodOpen Access

DNA methylation variability in pediatric aplastic anemia contributes to T cell differentiation

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Authors

JLJunchen LaiFCFangli ChenMYMiao Yan

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Overview

Cohort analysis shows DNA methylation variability affects T cell differentiation in pediatric aplastic anemia, indicating potential immunotherapy targets.

Key Points

  • This research aims to explore the role of DNA methylation in T cell differentiation within pediatric aplastic anemia.
  • Compared T cell characteristics of 76 pediatric aplastic anemia patients with 20 healthy controls
  • Utilized multi-omics approach including flow cytometry, whole genome bisulfite sequencing, and single-cell RNA sequencing
  • Analyzed DNA methylation patterns particularly focusing on STAT3 genes
  • Increased T cell proportions and higher Th17/Treg ratio observed in aplastic anemia patients
  • DNA methylation analysis revealed hypomethylation of STAT3 genes
  • IL-6/JAK2/STAT3 signaling pathway implicated in CD4+ T cell expansion and differentiation

Cite This Study

Lai et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d229https://doi.org/10.1182/blood-2025-1417
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive multiproteomic analysis reveals an inflammatory phenotype in immune aplastic anemia characterized by broad activation of antigen presenting cells and t helper/cytotoxic 1.17 immune responses2025
  2. 2Integrative clinical and molecular analysis of outcome in elderly African ancestry Acute Myeloid Leukemia2025
  3. 3Deep immune signature of immune-mediated aplastic anemia patients shows distinct subsets of regulatory T cells associated with response to treatment: Results from the phase 3, randomized EBMT race clinical trial2025
  4. 4Multi-omics analysis links NFKB1 activation to poor immunosuppressive therapy response in acquired aplastic anemia2025 · 1 citations
  5. 5Pediatric Acute Myeloid Leukemia associated S100A9 promotes T cell dysfunction2025