December 8, 2025Blood

A novel prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction syndrome

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To develop a prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction syndrome.
Retrospective cohort of adults with sickle cell disease at University of Illinois, Chicago.
Clinical data extracted and validated via chart review, focusing on bilirubin as a severity marker.
Survival analysis conducted using Kaplan-Meier curves and Cox proportional hazards models.
Over 44% mortality observed in the cohort, with significantly worse outcomes in major sinusoidal obstruction syndrome cases.
Elevated lactate dehydrogenase and alanine aminotransferase were linked to increased mortality risk.
The new model achieved a C-index of 0.88, outperforming the traditional MELD score.

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Implication

Retrospective cohort study identified bilirubin and hepatic markers indicating high mortality in adults with sickle cell disease with severe sinusoidal obstruction syndrome.

Cite This Study

Adam E. Mikolajczyk (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1ed https://doi.org/10.1182/blood-2025-532

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Implication

Retrospective cohort study identified bilirubin and hepatic markers indicating high mortality in adults with sickle cell disease with severe sinusoidal obstruction syndrome.

A novel prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction syndrome

Key Points

Discussion

Implication

Cite This Study

A novel prognostic model for predicting mortality in adults with sickle cell disease and severe sinusoidal obstruction syndrome

Key Points

Discussion

Implication

Cite This Study