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December 8, 2025PLoS Computational BiologyOpen Access

Coexistence rules for small, antagonistically interacting microbial communities

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Authors

GAGaurav S. AthreyaCGChaitanya S. GokhalePVPrateek Verma

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Overview

Graph theory reveals coexistence patterns in microbial diversity, suggesting the role of resistance and degradation.

Key Points

  • This research investigates how antibiotic-mediated interactions affect microbial diversity and coexistence.
  • Utilized graph theory to analyze interaction patterns of microbial communities.
  • Conducted simulations to explore the role of antibiotic production, resistance, and degradation.
  • Examined producer-sensitive-degrader motifs and cyclic interactions in communities.
  • Identified critical motifs that support coexistence in antibiotic interactions.
  • Showed that community coexistence is resilient across varying diffusivities of antibiotics and degraders.
  • Demonstrated that antagonism between microbes does not hinder biodiversity.

Cite This Study

Athreya et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1b4https://doi.org/10.1371/journal.pcbi.1013763
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbial interactions in facilitating antibiotic activity and resistance evolution2026
  2. 2Spatial proximity dictates bacterial competition and expansion in microbial communities2025
  3. 3Pairwise interactions and serial bottlenecks help explain species composition in a multispecies microbial community2026 · 1 citations
  4. 4Phase separation and coexistence in spatial coordination games between microbes2025
  5. 5Ecological Kinetics and Evolutionary Dynamics of Antibiotic Resistance in Complex Environments2025